Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings

OBJECTIVES The aim of this study was to calculate the horizontal growth rate of melanoma in vivo and to correlate it with morphologic findings. PATIENTS AND METHODS We searched our database for melanomas for which sequential dermatoscopic images and histopathologic slides were available. The final sample consisted of 50 melanomas of 48 patients (mean age: 50 ± 15 years, 62% females). We calculated the horizontal growth rate in mm(2) per year by morphometric analysis of digital dermatoscopic images. Dermatoscopic and dermatopathologic findings were assessed according to predefined criteria and correlated with the horizontal growth rate. RESULTS The median time interval between baseline and follow-up image was 12 months (range: 2-100 months). The majority of melanomas were in situ (n=28, 56%). The mean horizontal growth rate of all melanomas was 5.3 mm(2)/year (SD: ± 5.8 mm(2)/year). The histopathologic findings of numerous and large epidermal nests were associated with rapid growth. This histopathologic pattern corresponded to a pattern of clods ("globules") dermatoscopically. From a dermatoscopic point of view, melanomas with a main pattern of clods grew significantly faster (mean horizontal growth rate: 10.4 mm(2)/year, 95% CI: 6.4-14.4 mm(2)/year) than melanomas with mainly a reticular pattern (4.8 mm(2)/year, 95% CI: 2.7-7.0 mm(2)/year) or with other patterns (2.6 mm(2)/year, 95% CI: -0.5-5.6 mm(2)/ year, p=0.01). CONCLUSION Morphologic characteristics of melanoma are associated with biologic behavior. Large and numerous epidermal nests (corresponding to a pattern of clods dermatoscopically) indicate more rapid growth.